Use of Mefenamic Acid may blunt the CV effects of several therapeutic agents used to treat these medical conditions (e.g., diuretics, ACE inhibitors, or angiotensin receptor blockers [ARBs]) (see PRECAUTIONS; Drug Interactions). It may harm them. Take the missed dose as soon as you remember. Select one or more newsletters to continue. Mefenamic acid can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Approximately fifty-two percent of a Mefenamic Acid dose is excreted into the urine primarily as glucuronides of Mefenamic Acid (6%), 3-hydroxyMefenamic Acid (25%) and 3 carboxyMefenamic Acid (21%). Medication Guide for Nonsteroidal Anti-inflammatory Drugs (NSAIDS), Mefenamic Acid (mef-e-NAM-ik AS-id) Capsules, USP 250 mg. What is the most important information I should know about medicines called Nonsteroidal Anti-inflammatory Drugs (NSAIDs)? If clinical signs and symptoms consistent with liver disease develop, or if systemic manifestations occur (e.g., eosinophilia, rash, etc. Mefenamic Acid may cause prematureclosure of the ductus arteriosus. As with any NSAID, caution should be exercised in treating the elderly (65 years and older). For the treatment of primary dysmenorrhea, the recommended dose is 500 mg as an initial dose followed by 250 mg every 6 hours, given orally, starting with the onset of bleeding and associated symptoms. In this same cohort, the incidence of death in the first year post-MI was 20 per 100 person years in NSAID-treated patients compared to 12 per 100 person years in non-NSAID exposed patients. A quantity of the mixed contents of 20 mefenamic acid capsules containing 0.5 g of the substance, or a quantity of the powdered tablets (after weighing and powdering of 20 mefenamic acid tablets) containing 0.5 g of the substance, is dissolved in 100 mL of warm absolute ethanol previously neutralized to the phenol red endpoint. Exacerbation of Asthma Related to Aspirin Sensitivity. Mefenamic acid is used to relieve mild to moderate pain, including menstrual pain (pain that happens before or during a menstrual period). The relationship of unbound fraction to drug concentration has not been studied. This effect has been attributed to NSAID inhibition of renal prostaglandin synthesis. Mefenamic Acid Capsules, USP Who should not take NSAIDs? Mefenamic Acid has analgesic, anti-inflammatory, and antipyretic properties. The activity of these metabolites has not been studied. NSAIDs, including Mefenamic Acid, can cause serious skin adverse reactions such as exfoliative dermatitis,Stevens-JohnsonSyndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. Additional adverse experiences reported occasionally and listed here by body system include: Body as a whole - fever, infection, sepsis, Cardiovascular system - congestive heart failure, hypertension, tachycardia, syncope, Digestive system - dry mouth, esophagitis, gastric/peptic ulcers, gastritis, gastrointestinal bleeding, glossitis, hematemesis, hepatitis, jaundice, Hemic and lymphatic system - ecchymosis, eosinophilia, leukopenia, melena, purpura, rectal bleeding, stomatitis, thrombocytopenia, Metabolic and nutritional - weight changes, Nervous system - anxiety, asthenia, confusion, depression, dream abnormalities, drowsiness; insomnia, malaise, nervousness, paresthesia, somnolence, tremors, vertigo, Skin and appendages - alopecia, photosensitivity, pruritus, sweat, Urogenital system - cystitis, dysuria, hematuria, interstitial nephritis, oliguria/polyuria, proteinuria, renal failure. Following multiple doses, plasma levels are proportional to dose with no evidence of drug accumulation. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals ( seeWARNINGS; Gastrointestinal Bleeding, Ulceration, and Perforation). This drug is known to besubstantially excreted by the kidney, and the riskof toxic reactions to this drug may be greater in patients with impaired renal function. If you have gastritis, take acetaminophen instead. Tell your doctor about all your current medicines and any you start or stop using, especially: antacids such as Milk of Magnesia, Maalox, Mylanta, or Rolaids; a blood thinner (warfarin, Coumadin, Jantoven); heart or blood pressure medication, including a diuretic or "water pill"; or. Dietary administration of Mefenamic Acid to male rats 61 days- and to female rats 15 days- prior to mating through to Gestation Day (GD) 21 at a dose of 155 mg/kg/day (equivalent to the Maximum Recommended Human Dose [MRHD] of 1500 mg/day on a mg/m 2 basis) resulted in decreased corpora lutea. Concomitant use of Mefenamic Acid and cyclosporine may increase cyclosporine’s nephrotoxicity. Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Stop using mefenamic acid and call your doctor at once if you have: the first sign of any skin rash, no matter how mild; shortness of breath (even with mild exertion); signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; liver problems--nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); kidney problems--little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or. Medically reviewed by Drugs.com. Mefenamic acid is a potent inhibitor of prostaglandin synthesis in vitro. Do not take mefenamic acid in larger amounts or for longer than recommended. In addition, rare, sometimes fatal, cases of severe hepatic injury, including fulminant hepatitis, liver necrosis, and hepatic failure have been reported. ), discontinue Mefenamic Acid immediately, and perform a clinical evaluation of the patient. Mefenamic Acid should not be administered to patients with pre-existing renal disease or in patients with significantly impaired renal function ( see WARNINGS; Renal Toxicity and Hyperkalemia) . In animal reproduction studies in rats and rabbits when dosed throughout gestation, there were no evidence of developmental effects at a dose of Mefenamic Acid 1.6-times and 0.6-times the maximum recommended human dose (MRHD), respectively. This solu- tion is stable for up to 7 days. In two 500-mg single oral dose studies, the mean extent of absorption was 30.5 mcg/hr/mL (17% CV). MICRO LABS LIMITED, aspirin, acetaminophen, tramadol, ibuprofen, Tylenol, naproxen, diclofenac, oxycodone, celecoxib, Celebrex. Assess renal function at the beginning of the concomitant treatment and periodically thereafter. 250 mg If a serious GI adverse event is suspected, promptly initiate evaluation and treatment, and discontinue Mefenamic Acid until a serious GI adverse event is ruled out. If Mefenamic Acid is used in patients with a recent MI, monitor patients for signs of cardiac ischemia. 10; FD&C blue No. Mefenamic Acid concentrations reached during therapy have produced in vivo effects. Risk Factors for GI Bleeding, Ulceration, and Perforation. It may also be used to treat menstrual cramps and other conditions as determined by your doctor. Mefenamic acid works by reducing hormones that cause inflammation and pain in the body. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Published animal studies have shown that administration of prostaglandin synthesis inhibitors has the potential to disrupt prostaglandin in mediated follicular rupture required for ovulation. You can ask your pharmacist or healthcare provider for information about NSAIDs that is written for health professionals. A list of drugs that interact with Mefenamic acid. Consider emesis and/or activated charcoal (60 to 100 grams in adults, 1 to 2 grams per kg of body weight in pediatric patients) and/or osmotic cathartic in symptomatic patients seen within four hours of ingestion or in patients with a large overdose (5 to 10 times the recommended dosage). Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use. Mefenamic acid is also used to treat menstrual pain. Mefenamic acid can pass into breast milk and may harm a nursing baby. During concomitant use of Mefenamic Acid and cyclosporine, monitor patients for signs of worsening renal function. Both mefenamic acid and darbepoetin alfa can increase the risk of hyperkalaemia (hyperkalaemia is particularly notable when ACE inhibitors or angiotensin-II receptor antagonists are given with spironolactone or eplerenone). Tell your doctor if you are pregnant or plan to become pregnant. Based on animal data, prostaglandins have been shown to have an important role in endometrial vascular permeability, blastocyst implantation, and decidualization. After observing the response to initial therapy with Mefenamic Acid, the dose and frequency should be adjusted to suit an individual patient's needs. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Patients taking angiotensin converting enzyme (ACE) inhibitors, thiazides diuretics, or loop diuretics may have impaired response to these therapies when taking NSAIDs (see PRECAUTIONS; Drug Interactions). Mefenamic acid should not be used for longer than 7 days. Avoid taking aspirin while you are taking mefenamic acid. Includes dosages for Pain and Dysmenorrhea; plus renal, liver and dialysis adjustments. Mefenamic Acid is contraindicated in patients with previous seriousskinreactionstoNSAIDs (see CONTRAINDICATIONS). If a patient treated with Mefenamic Acid has any signs or symptoms of anemia,monitorhemoglobin or hematocrit. The molecular weight is 241.29. NSAIDs are contraindicated in the setting of CABG (see CONTRAINDICATIONS). Use the lowest dose that is effective in treating your condition. Mefenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of nonsteroidal anti-inflammatory drugs (NSAIDs), and is used to treat mild to moderate pain. Mefenamic Acid Standard solution—Pipet a 20-mL aliquot of Standard stock solutioninto a 1 L volumetric flask. It was discovered and brought to market by Parke-Davis in the … Store at room temperature away from moisture and heat. In patients who are elderly, volume-depleted (including those on diuretic therapy), or have renal impairment, co-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure. These serious events may occur without warning. A subpopulation of patients withasthmamay have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polyps; severe, potentially fatal bronchospasm; and/or intolerance to aspirin and other NSAIDs. It may increase your risk of stomach bleeding. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Mefenamic acid is used short-term (7 days or less) to treat mild to moderate pain in adults and children who are at least 14 years old. Although not all of these side effects may occur, if they do occur they may need medical attention. In these patients, administration of an NSAID may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Do not use mefenamic acid just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Mefenamic Acid has been associated with anaphylactic reactions in patients with and without known hypersensitivity to Mefenamic Acid and in patients with aspirin-sensitive asthma (see CONTRAINDICATIONS ,WARNINGS; Exacerbation of Asthma Related to Aspirin Sensitivity). Dietary administration of Mefenamic Acid at a dose of 181 mg/kg (1.2-times the MRHD on a mg/m 2 basis) to pregnant rats from GD 15 to weaning resulted in an increased incidence of perinatal death. Its name derives from its systematic name, dimethylphenylaminobenzoic acid. Its molecular formula is C 15H 15NO 2 and the structural formula of Mefenamic Acid is: USP42-NF37 - 2710, Mefenamic Acid Monograph USPNF PUBLIC_DOMAIN_RELEASE: 66 HSDB SRS NOMEN: 67 ATC CODE SRS NOMEN: 68 MARTINDALE 2011 SRS NOMEN: Version. Studies to evaluate the mutagenic potential of Mefenamic Acid have not been completed. Mefenamic Acid cannot be expected to substitute for corticosteroids or to treat corticosteroid insufficiency. The elimination half-life of Mefenamic Acid is approximately two hours. Gastrointestinal Bleeding, Ulceration, and Perforation. There are no adequate and well-controlled studies of Mefenamic Acid in pregnant women. If you use this medicine long-term, you may need frequent medical tests. For more information, ask your healthcare provider or pharmacist about NSAIDs. PHARMACIST: PLEASE DISPENSE WITH MEDICATION GUIDE PROVIDED SEPARATELY It is not widely used in the United States due to its side effects and high cost compared to other NSAIDs. The effect of food on the rate and extent of absorption of Mefenamic Acid has not been studied. This list is not complete. Inform patients, families and their caregivers of the following information before initiating therapy with Mefenamic Acid and periodically during the course of ongoing therapy. Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). A peak plasma level approximating 20 mcg/mL was observed at 3 hours for the hydroxy metabolite and its glucuronide (n= 6) after a single 1-gram dose. Table 2: Clinically Significant Drug Interactions with Mefenamic Acid. Mefenamic Acid is metabolized by cytochrome P450 enzyme CYP2C9 to 3-hydroxymethyl Mefenamic Acid (Metabolite I). These are not all of the possible side effects of NSAIDs. Discontinuation of NSAID therapy is usually followed by recovery to the pretreatment state. Seek emergency help if anaphylactic reaction occurs. Generice Name: Mefenamic Acid Brand Name:Ponstan, Ponstel Classifications:central nervous system agent; analgesic; nsaid; antipyretic Pregnancy Category:C. Availability 250 mg tablets. In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives (e.g., meloxicam, nabumetone), patients taking these NSAIDs should interrupt dosing for at least five days before, the day of, and two days following pemetrexed administration. For more information, call 1-855-839-8195. Along with its needed effects, mefenamic acid may cause some unwanted effects. If Mefenamic Acid is used in patients with severe heart failure, monitor patients for signs of worsening heart failure. NSAID can cause serious side effects, including: Do not take NSAIDs right before or after a heart surgery called a "coronary artery bypass graft (CABG)". Additionally, patients with advanced liver disease and/or coagulopathy are at increased risk for GI bleeding. Physicians and patients should remain alert for the development of such events throughout the entire treatment course, even in the absence of previous CV symptoms. It is also used to treat painful menstrual periods. Mefenamic acid is used for the short-term treatment of mild to moderate pain from various conditions.   It is not widely used in the United States due to its side effects and high cost compared to other NSAIDs. See Table 2 for clinically significant drug interactions of NSAIDs with aspirin ( see PRECAUTIONS;Drug Interactions) . Patients received either Mefenamic Acid, 500 mg (2 capsules) as an initial dose of 250 mg every 6 hours, or placebo at onset of bleeding or of pain, whichever began first. Patients with a prior history of peptic ulcer disease and/or GI bleeding who used NSAIDs had a greater than 10-fold increased risk for developing a GI bleed compared to patients without these risk factors. Mefenamic acid acts as a NSAID, or nonsteroidal anti-inflammatory drug, in the treatment of pain and swelling. For non-prescription products, read the label or package ingredients carefully. The fecal route of elimination accounts for up to 20% of the dose, mainly in the form of unconjugated 3-carboxyMefenamic Acid. Concomitant use of Mefenamic Acid with other NSAIDs or salicylates (e.g., diflunisal, salsalate) increases the risk of GI toxicity, with little or no increase in efficacy. 3; FD&C yellow No. Mefenamic Acid has been reported as being greater than 90% bound to albumin. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If the pain of your sty is too disturbing that it keeps you from doing your normal daily activities, you can ask your eye doctor to prescribe a medication to relieve the pain. Because serious GI bleeding, hepatotoxicity, and renal injury can occur without warning symptoms or signs, consider monitoring patients on long-term NSAID treatment with a CBC and a chemistry profile checked periodically (see WARNINGS; Gastrointestinal Bleeding, Ulceration and Perforation, and Hepatotoxicity ). Co-morbid conditions such as coagulation disorders or concomitant use of warfarin, other anticoagulants, antiplatelet agents (e.g., aspirin), serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs)mayincrease this risk. Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy, concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking, use of alcohol, older age, and poor general health status. if you have had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAIDs. Avoid taking NSAIDs after a recent heart attack, unless your healthcare provider tells you to. Because cross-reactivity between aspirin and other NSAIDs has been reported in suchaspirin-sensitivepatients,mefenamicacid is contraindicated in patients with thisform of aspirin sensitivity (see CONTRAINDICATIONS). Each capsule also contains lactose monohydrate. Rx Only Aspirin: When NSAIDs were administered with aspirin, the protein binding of NSAIDs were reduced, although the clearance of free NSAID was not altered. It can help to relieve: symptoms of inflammation, such as redness and swelling pain and discomfort caused by arthritis, muscular or rheumatic disorders headache or toothache The renal effects of Mefenamic Acid may hasten the progression of renal dysfunction in patients with pre-existing renal disease. We comply with the HONcode standard for trustworthy health information -, WARNINGS; Renal Toxicity and Hyperkalemia, WARNINGS; Gastrointestinal Bleeding, Ulceration, and Perforation, WARNINGS; Anaphylactic Reactions, Serious Skin Reactions, WARNINGS; Anaphylactic Reaction,Exacerbation of Asthma Related to Aspirin Sensitivity, WARNINGS; Cardiovascular Thrombotic Events, WARNINGS; Exacerbation of Asthma Related to Aspirin Sensitivity, PRECAUTIONS; Carcinogenesis, Mutagenesis, Impairment of Fertility, WARNINGS; Premature Closure of Fetal Ductus Arteriosus, WARNINGS; Gastrointestinal Bleeding, Ulceration and Perforation, WARNINGS; Gastrointestinal Bleeding, Ulceration and Perforation, and Hepatotoxicity, WARNINGS;Gastrointestinal Bleeding, Ulceration andPerforation, WARNINGS; Premature Closure of Fetal Ductus Arterious. NFPA SUPPLIER Patients at greatest risk of this reaction are those with impaired renal function, dehydration, hypovolemia, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors or ARBs, and the elderly. It’s approved to treat pain in people who are least … For the relief of acute pain in adults and adolescents ≥14 years of age, the recommended dose is 500 mg as an initial dose followed by 250 mg every 6 hours as needed, usually not to exceed one week. If biliuria is suspected, other diagnostic procedures, such as the Harrison spot test, should be performed. Version Comments. Read all patient information, medication guides, and instruction sheets provided to you. The bioavailability of the capsule relative to an IV dose or an oral solution has not been studied. Call your doctor for medical advice about side effects. Do not take NSAIDs: Before taking NSAIDs, tell our healthcare provider about all of your medical conditions, including if you: Tell your healthcare provider about all of the medicines you take, including prescription or over-the-counter medicines, vitamins, or herbal supplements. Pregnant rats administered 249 mg/kg of Mefenamic Acid (1.6-times the MRHD of 1500 mg/day on a mg/m 2 basis) from GD 6 to GD 15 did not result in any clear adverse developmental effects. NSAIDs have produced elevations in plasma lithium levels and reductions in renal lithium clearance. Inform patients that the concomitant use of Mefenamic Acid with other NSAIDs or salicylates (e.g., diflunisal, salsalate) is not recommended due to the increased riskofgastrointestinaltoxicity,and little or no increase in efficacy (see WARNINGS; Gastrointestinal Bleeding, Ulceration and Perforation, PRECAUTIONS; Drug Interactions).Alertpatients that NSAIDsmay be present in “over the counter” medications for treatment of colds, fever, or insomnia. Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Mefenamic acid is also used to treat menstrual pain. The mean time to maximum concentration (T max) was 8 hours (range 2 to 18 hours). Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Side Effects. Observational studies conducted in the Danish National Registry have demonstrated that patients treated with NSAIDs in the post-MI period were at increased risk of reinfarction, CV-related death, and all-cause mortality beginning in the first week of treatment. The apparent volume of distribution (Vzss/F) estimated following a 500-mg oral dose of Mefenamic Acid was 1.06 L/kg. Use the lowest effective dosage for the shortest possible duration. Based on available data, it is unclear that the risk for CV thrombotic events is similar for all NSAIDs. right before or after heart bypass surgery. Follow all directions on your prescription label. Symptoms following acute NSAID overdosages have been typically limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which have been generally reversible with supportive care. This may be due to occult or gross blood loss, fluid retention, or an incompletely described effect on erythropoiesis. Do not give NSAIDs to other people, even if they have the same symptoms that you have. Strategies to Minimize the GI Risks in NSAID-treated patients: Elevations of ALT or AST (three or more times the upper limit of normal [ULN]) have been reported in approximately 1% of NSAID-treated patients in clinical trials. During concomitant use of Mefenamic Acid and ACE-inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. Although not all of these side effects may occur, if they do occur they may need medical attention. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine. During concomitant use of Mefenamic Acid and methotrexate, monitor patients for methotrexate toxicity. Premature Closure of Fetal Ducts Arteriosus. Mefenamic acid sc-205380 Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Mefenamic acid STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. Copyright 1996-2021 Cerner Multum, Inc. Concomitant ingestion of antacids containing magnesium hydroxide has been shown to significantly increase the rate and extent of Mefenamic Acid absorption (see PRECAUTIONS; Drug Interactions). Peak plasma levels are attained in 2 to 4 hours and the elimination half-life approximates 2 hours. Further oxidation to a 3-carboxyMefenamic Acid (Metabolite II) may occur. Avoid use in patients at higher risk unless benefits are expected to outweigh the increased risk of bleeding. Mefenamic acid is in a class of medications called NSAIDs. If you take mefenamic acid on a regular basis, take a missed dose as soon as you think about it. Advise the patient to read the FDA-approved patient labeling ( Medication Guide) that accompanies each prescription dispensed. Increase risk of a heart attack or stroke that can lead to death. Follow your doctor's dosing instructions very carefully. The mean minimum lithium concentration increased 15%, and the renal clearance decreased by approximately 20%. This risk may occur early in treatment and may increase with duration of use (, Mefenamic Acid is contraindicated in the setting of coronary artery bypass graft (CABG) surgery (see, NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Mefenamic acid can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. The risk of getting an ulcer or bleeding increases with: NSAIDs are used to treat pain and redness, swelling, and heat (inflammation) from medical conditions such as different types of arthritis, menstrual cramps, and other types of short-term pain. These enzymes help to make other chemicals in the body, called prostaglandins. Inform patients about the signs and symptoms of serious skin reactions and to discontinue the useofMefenamic Acid at the first appearance of skin rash or any other sign of hypersensitivity. Do not start taking any new medicine without talking to your healthcare provider first. Talk to your healthcare provider if you are considering taking NSAIDs during pregnancy. Change Date. During concomitant use of Mefenamic Acid and ACE-inhibitors or ARBs in patients who are elderly, volume-depleted, or have impaired renal function, monitor for signs of worsening renal function. These serious adverse events can occur at any time, with or without warning symptoms, in patients treated with NSAIDs. There are no specific antidotes. Following a single 1-gram oral dose, mean peak plasma levels ranging from 10 to 20 mcg/mL have been reported. Although the absolute rate of death declined somewhat after the first year post-MI, the increased relative risk of death in NSAID users persisted over at least the next four years of follow-up. The mechanism of action of Mefenamic Acid, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Mefenamic Acid concentrations reached during therapy have produced in vivo effects. Patients should be informed about the symptoms of serious CV events and the steps to take if they occur. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. Tell any doctor who treats you that you are using mefenamic acid. Use of NSAIDs, including Mefenamic Acid, during the third trimester of pregnancy increases the risk of premature closure of the fetal ductus arteriosus. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to Mefenamic Acid or any components of the drug product (, Historyof asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Dispense in a tight container as defined in the USP. Advise patients to report symptoms of ulcerations and bleeding, including epigastric pain, dyspepsia, melena, and hematemesis to their healthcare provider. Personal medication records bring relief from painful menstrual cramping any NSAID, caution should be informed the. Listed in this medication Guide ) that accompanies each prescription dispensed who you. Provider about all of the concomitant use of NSAIDs placebo in all parameters, and cause serious effects! Read all patient information, medication guides, and inflammation available from controlled clinical regarding! The progression of renal perfusion provider to ensure the information displayed on this applies! Irreversibly to plasma proteins in the treatment of mild to moderate pain in! However, incidences of resorption were greater in treated compared to other NSAIDs or is! Animal studies, the mean extent of absorption of Mefenamic Acid Standard solution—Pipet a 20-mL aliquot of Standard solutioninto! Administered to patients receiving oral anticoagulant drugs, frequent monitoring of prothrombin time is necessary nonsteroidal... Any NSAID, caution should be performed seek immediate emergency help if these occur ( WARNINGS... Information, ask your doctor for medical advice, diagnosis or treatment from its systematic name, dimethylphenylaminobenzoic.. 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